Identification of a Mycobacterium tuberculosis strain with stable, low-level resistance to isoniazid.

نویسندگان

  • Bereneice M Madison
  • Salman H Siddiqi
  • Leonid Heifets
  • Wendy Gross
  • Mike Higgins
  • Nancy Warren
  • Anthony Thompson
  • Glenn Morlock
  • John C Ridderhof
چکیده

We have identified a potential quality control strain of Mycobacterium tuberculosis to monitor isoniazid susceptibility testing. This strain (strain A) has a stable phenotypic low-level resistance to isoniazid, has a mutation of C (-15) --> T in the inhA promoter region, and gave consistent susceptibility test results in 141 laboratories.

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عنوان ژورنال:
  • Journal of clinical microbiology

دوره 42 3  شماره 

صفحات  -

تاریخ انتشار 2004